The medicines we develop and deliver to our customers help one million patients each day. With an increasing demand for our services, expertise and capabilities, comes a commitment to continuously expand our products and services. This is why we have been making unprecedented investments in our network of sites and capabilities around the world.
Our investment is not just about adding capacity—it’s about enhancing capabilities across our Pharma Services business. By drawing on the collective expertise from businesses across Thermo Fisher, expanding our network of best-in-class facilities, and strengthening our workforce with exceptional talent, we provide solutions to our customers that enable them to accelerate innovation and productivity and get medicines to their patients faster.
Learn more about our newly expanded capabilities below.
To accelerate demand for cell and gene vaccines and therapies globally, Thermo Fisher and Groupe Novasep SAS (Novasep), a leading supplier of services and technologies for the life sciences industry, announced that Thermo Fisher has completed the acquisition of Henogen S.A., Novasep’s viral vector manufacturing business in Belgium. Novasep’s viral vector manufacturing business provides contract manufacturing services to biotechnology companies and large biopharma customers. With two locations in Seneffe and Gosselies, Belgium, Novasep’s viral vector business offers more than 7,000 square meters of state-of-the-art clinical and commercial manufacturing capacity. Founded more than 20 years ago, the business has approximately 400 employees with substantial operational and technical expertise in a broad range of viral vector classes.
To accelerate commercialization of plasmid-based medicines and vaccines, Thermo Fisher is constructing a new cGMP plasmid DNA manufacturing facility in Carlsbad, CA. The new site will expand the company’s clinical and commercial capabilities for cGMP plasmid DNA used as a critical raw material to develop and manufacture cell and gene-based therapies including life-saving cancer treatments and mRNA vaccines. The site will also have the capability to produce large-scale plasmid DNA as a primary drug substance for DNA therapies. The 67,000 square foot facility, expected to be completed in the first half of 2021, will have advanced technologies, including single use equipment with up to 1,000L scale, digital connectivity and data visibility to enable operational efficiencies and operator training, and add approximately 150 jobs over the next 12 months.
To support increasing demand for viral vector development and manufacturing services, Thermo Fisher is expanding capacity with construction of a new commercial manufacturing site in Plainville, Mass. The 290,000-square-foot facility will more than double the company’s commercial viral vector capacity to support customers who are developing and manufacturing gene therapies and vaccines to address unmet medical needs. Construction at the Plainville site will be complete in 2022, adding more than 200 jobs and complementing new or recently expanded capacity in Lexington and Cambridge, Mass., and Alachua, Fla. The Plainville site will offer a flexible and scalable configuration of laboratory and production suites co-located with adjacent warehousing and office space. An onsite engineering laboratory will help customers develop turnkey production platforms that enable them to rapidly transition to commercial-scale operations when ready.
Building on a 12+ year track record of supplying first-in-human clinical materials at our Alachua, Florida, site, we’ve invested over $3 million into an expansion that will double the upstream process development capacity, establish commercial QC testing, and offer a new offsite warehouse space. The expansion of this site will allow for more at scale development, enabling better technology transfer to GMP and increasing the probability for success for our clients’ gene therapy products. The expansion will ultimately enable our clients to bring more advanced medicines to patients.
Our $93 million investment in expanding our site in Lexington, Massachusetts, includes full renovation of a 50,000-square-foot facility for viral vector manufacturing and commercial manufacturing of viral vectors. The renovation added eight new drug substance suites and one new drug product suite, a GMP manufacturing support area, new QC labs, a manufacturing sciences lab, short-term warehouse space and office space. Through this investment, we are accelerating advancements in gene therapy and enabling our clients to get these transformative medicines to patients in need, increasing the number of patients benefiting from breakthrough medicines for rare and complex diseases.
Our investment of $40 million in added capacity at our Cambridge, Massachusetts, site further expanded our Viral Vector Services’ CDMO services, offering customers increased access to capacity at a variety of scales and with a personalized manufacturing approach that is focused on safety, quality, process robustness and fulfillment of their program goals. Opened in the fall of 2019, this expansion added four drug substance suites and one drug product suite, plus additional manufacturing support space and utility area.
On November 6, Thermo Fisher announced that we have signed a joint venture agreement with Innoforce, a bioinnovation-enabling company, to establish a new pharma services facility in Hangzhou, China, for integrated biologics drug substance and steriles drug product development and manufacturing. The new facility is expected to be completed in 2022. Read the press release.
The addition of the Hangzhou site will expand our existing global pharma services network and provide drug development and manufacturing services for customers in China, as well as for global customers seeking capabilities in the region. Together with Innoforce, Thermo Fisher will offer fully-integrated global capabilities from molecule to medicine to our customers and the patients they serve.
“A large portion of China’s clinical pipeline is owned by new and emerging companies and there is an increasing need for expertise and capabilities to enable customers to accelerate their development of medicines for patients around the world,” said Mike Shafer, President, Pharma Services. “Innoforce’s expertise allows us to expand our existing network and provides critical support for customers of all sizes that are ready to start in China, enter China or expand beyond China.”
The new facility will further expand Thermo Fisher’s footprint in China, which includes more than 5,000 employees across 14 commercial offices and eight manufacturing sites. Upon mechanical completion, the Hangzhou site will become part of our global biologics and steriles network, with sites across the U.S., Europe and Asia Pacific, including a recently announced Singapore facility facility with new high-speed sterile fill capabilities.
“Our commitment to China is evident in our long history of strategic investments, and our joint venture with Innoforce is yet another example,” said Tony Acciarito, President, Thermo Fisher China. “We will continue to build new product development and manufacturing capabilities in China to support our biopharma customers in their efforts to bring innovative medicines to market.” Until the site is operational, new and existing customers can access our current global network of biologics and sterile fill-finish capacity. After completion, projects will seamlessly transition to the new Hangzhou site.
Innoforce is located in the heart of Hangzhou Bay Biotech Valley within the Hangzhou Airport Economic Demonstration Area. Its founders and management team have extensive international biopharmaceutical experience and expertise across technology innovation, product development and business operations. The first phase of the Innoforce campus covers 21 acres including biologic process development laboratories, scale-up and R&D labs, and manufacturing facilities for protein, cell and gene therapies. For more information, please visit www.innoforcepharma.com.
To enhance our offering with expanded capabilities in order to meet the growing demand for biologic therapies, we’ve entered into a strategic partnership with CSL. Under the agreement, we’ll become CSL’s strategic pharma services partner supporting their product portfolio across our network with capabilities, including drug product development, sterile fill/finish, packaging and clinical trials logistics. Additionally, CSL will transfer operations and oversight of its state-of-the-art biologics manufacturing facility, currently under construction, in Lengnau, Switzerland, to Thermo Fisher. when construction is completed in mid-2021. Until mechanical completion of the site, we will operate as two separate companies.
With the addition of the Lengau site to our network, we gain access to a world-class facility to support highly flexible bioproduction technologies, including Single-Use and Stainless Steel, providing a pathway from development to large-scale production. This will enable our customers to easily get started with us and stay with us as their needs expand.
To learn more about this unique partnership, see links below.
Our $50 million investment in our St. Louis, Missouri, site increased manufacturing space by 62,000 ft2, doubling production capacity. At the end of 2019, the first GMP batch produced in the new facility met all client acceptance criteria.
The expansion provides infrastructure that will allow us to anticipate and enable future expansions to occur even faster. The new capabilities also substantially increase our ability to meet the clinical and commercial manufacturing needs of our growing client base, helping us advance medicines to patients in need.
Bioprocessing Collaboration Center (BCC)
The new Bioprocessing Collaboration Center (BCC) in St. Louis, Missouri, uniquely positions Thermo Fisher to bring together industry-leading expertise in single-use technologies and biologics product development and manufacturing to deliver unmatched value to our customers.
The facility is adjacent to our biologics manufacturing facility, which recently doubled production capacity with a $50M expansion. The combined expertise from our bioproduction and pharma services businesses will accelerate innovation and enhance productivity for biopharma customers, enabling them to meet the growing need for more flexible, scalable biologics development and manufacturing solutions.
The team will work together to develop innovative bioprocessing technologies, products and services that will enhance bioprocess workflows and enable our customers to take their products to market faster and with greater efficiency. The BCC will bring together the company’s leadership in GMP biologics manufacturing with its deep expertise in bioprocessing technologies including bioreactors, cell culture media, chromatography, analytical tools, among others. This collaboration will deliver new single-use bioprocessing technologies as well as drive critical process, data management and quality improvements that enable scale-up solutions for biopharma customers.
Learn more about our new collaboration center:
The acquisition of our Cork, Ireland, facility expanded our world-class API development and commercial capabilities for customers around the world. Combined with the unique offerings across our network, the site’s capabilities enables our customers to help patients with a range of diseases and will allow us to bring important new products to market. The additional API capability and capacity also increases our Quick to CareTM integrated offering for drug substance and drug product to speed up the development process and simplify our customer’s supply chain.
Phase III Commercial spray drying is now available via the newly constructed MS-400 facility within our Florence, South Carolina, site. This new addition in scale means we can now offer full development capabilities by utilizing our network in Bend, Oregon, and Milton Park, UK, and late phase/commercialization services for spray drying. Spray drying offers a solution for products with bioavailability challenges.
To meet the rapidly growing global demand, Thermo Fisher is further expanding its pharma services footprint in North America and Europe for sterile drug product development and commercial manufacturing of critical medicines, therapies and vaccines. Over the next two years, the company’s global steriles network will add 15 development and commercial production lines to support a range of capabilities, including live virus, aseptic liquid and lyophilized vial filling. In Greenville, NC, the expansion includes a new standalone 130,000 square foot facility with two live virus filling lines, which is expected to be operational in 2022. The site will also add six new lines in 2021 and 2022 including commercial scale liquid filling lines and a development line for liquid and lyophilized drug products. Approximately 500 new roles will be hired in Greenville over the next 12-24 months.
To meet the rapidly growing global demand, Thermo Fisher is further expanding its pharma services footprint in North America and Europe for sterile drug product development and commercial manufacturing of critical medicines, therapies and vaccines. Over the next two years, the company’s global steriles network will add 15 development and commercial production lines to support a range of capabilities including, live virus, aseptic liquid and lyophilized vial filling. In Ferentino, Italy, the expansion includes one new line for high-capacity commercial liquid filing, which is expected to be ready for operation in 2021. In addition, a new 28,000 square foot development building will include one flexible line for development projects and small-scale commercial manufacturing that is expected to be operational in 2022. Approximately 200 new roles will be hired in Ferentino over the next 12-24 months.
To meet the rapidly growing global demand, Thermo Fisher is further expanding its pharma services footprint in North America and Europe for sterile drug product development and commercial manufacturing of critical medicines, therapies and vaccines. Over the next two years, the company’s global steriles network will add 15 development and commercial production lines to support a range of capabilities including, live virus, aseptic liquid and lyophilized vial filling. In Monza, Italy, the expansion includes three new sterile fill finish lines, including one high-capacity line for liquid and lyophilized filling for commercial production, one pre-filled syringe/pre-filled cartridge line for medium batch production and one flexible multi-purpose line for low volume filling. The new lines will be operational in 2021. More than 200 new roles will be hired in Monza over the next 12-24 months.
To meet the rapidly growing global demand, Thermo Fisher is further expanding its pharma services footprint in North America and Europe for sterile drug product development and commercial manufacturing of critical medicines, therapies and vaccines. Over the next two years, the company’s global steriles network will add 15 development and commercial production lines to support a range of capabilities including, live virus, aseptic liquid and lyophilized vial filling. In Swindon, the expansion will transform the 30,000 square foot site into a new full-scale commercial manufacturing facility with one line for liquid and one line for lyophilized filling, plus extensive cold chain storage for vaccines requiring ultra-low temperatures. The new site is expected to be operational in 2021. Approximately 200 new roles will be hired in Swindon over the next 12-24 months.
Sterile Filling Capacity for Therapies and Vaccines in the Asia Pacific Region
Thermo Fisher announced plans to develop two new sterile filling lines in Singapore to extend capacity to the Asia-Pacific region for the development and manufacture of therapies and vaccines. Established with the support of the Singapore Economic Development Board (EDB), the new facility, which will be operated by Thermo Fisher, will have the capability to manufacture pharmaceutical products during health emergencies. The new facility will initially include a high-speed sterile line approved for live virus filling—the first such large scale capability in Singapore—followed by an additional line for standard fill/finish. Once operational in 2022, the site could manufacture up to 30 million sterile doses per month and employ more than 300 people. This partnership enables us to expand our sterile fill finish network in the region while strengthening the Singapore government’s ability to respond quickly to future health crises in the region.
Lab of the Future
Thermo Fisher has invested $55 million in its Greenville, NC manufacturing site in 2019 to expand its capabilities and capacity for customers and the patients they serve. An investment in enhanced capabilities brings a commitment to build our workforce to strengthen our collaborative culture, deliver superior customer service and supporting local communities through growing career opportunities. One of those investments is the new Lab of the Future. The new Lab of the Future is a modular QC laboratory designed with Lean Manufacturing principles, state-of-the-art instrumentation, full instrument connectivity, laboratory automation and a leading-edge Informatics system to enable efficient and timely analytical results.
Pre-Filled Syringes (PFS)
The medicines we develop and deliver to our customers help one million patients each day, and the demand for our services, expertise and capabilities continues to increase. Our expanded capacity and capabilities address the growing need in the industry for high-quality sterile fill / finish services, which is being driven by the growth of biologic therapies. Adding the pre-filled syringes (PFS) capability is part of this expansion. The PFS market has increasing potential because it allows patients to treat themselves from home. It is convenient, affordable, patient-safe and accurate.
Virtual Training Center
Part of a $55 million investment in our Greenville, North Carolina, site, the new industry-leading Virtual Training Center is equipped with virtual reality and augmented reality capabilities to help advance the onboarding and training of personnel who will work on the sterile injectables drug production lines. The Virtual Training Center decreases training time from approximately a year to only four months, increases knowledge retention, and decreases the risk of deviations.
To meet accelerating demand for robust clinical supply chain services throughout Europe, Thermo Fisher has expanded its pharma services footprint with a new state-of-the-art facility in Rheinfelden, Germany. The new 86,000 square foot / 8,000 square meter facility significantly increases the company’s capability for secondary packaging, storage, logistics and distribution of clinical supplies to investigator sites across Europe. Featuring highly automated technology in a fully scalable, mixed-use space, the site will serve as a strategic logistics hub for shipping by road or air and its central location will help expedite clinical trial therapies to patients. The Rheinfelden site opens in late December 2020.
To meet accelerating demand for robust clinical supply chain services throughout Europe, Thermo Fisher has expanded its pharma services footprint with a new state-of-the-art facility in Weil am Rhein, Germany. The new 9,600 square foot / 890 square meter cryocenter provides specialized ultra-low-temperature, cryogenic storage and cold chain expertise for clinical supply chain needs for cell and gene-based therapies, including COVID-19 vaccines candidates. With deep expertise in end-to-end cold chain management, the cryocenter will support ultra-low temperature storage, packaging, labeling, and distribution required by vaccine and cell and gene therapy innovators. The site will feature -80°C freezers, liquid nitrogen (LN2) cryogenic storage tanks and walk-in 2-8°C and -20°C cold storage technology. The Weil am Rhein site will open in January 2021.
We invested $3 million to build a new state-of-the art center in Buenos Aires, Argentina. Opened in August 2019, the facility allows us to offer our expertise and capabilities to local clients with a focus on high quality secondary packaging solutions. The new site provides services in the areas of clinical trial support, including GMP storage, local labeling, secondary packaging, comparator sourcing, and handling and distribution of ambient and cold chain clinical trial supplies through to returns management.
In May 2019, we opened a new packaging and distribution facility in Ahmedabad, India, to better serve customer growth in India and their increasing need for clinical trial support focused on local products for India’s market. The facility addresses the growing demand for development supply chain services and specializes in high quality primary and secondary packaging solutions.
We announced that we will open a new $35 million state-of-the-art pharma services supply chain facility in Rheinfelden, Germany. The site will feature the latest technology and modern infrastructure to significantly increase European capacity for cold and ambient clinical trial materials in support of complex clinical research and to meet the growing needs of customers. The 8,000m2 facility will be scalable for mixed-use space, provide a strategic logistical location for shipping either by road or air, and has the option for an additional expansion that could double the footprint of the site.