Quadrant 2® – Solubility Enhancement

Patheon, by Thermo Fisher Scientific’s proprietary computational modeling program, Quadrant 2®, analyzes your compound’s specific molecular structure and chemical characteristics, in combination with your unique target product profile. Using your compound’s individualized data, Quadrant 2® can predict the most promising solubility enhancement technology and excipient combination to meet your clinical and business objectives, at the earliest stages of development. This exclusive, scientifically-based algorithm eliminates solubility enhancement options that are unlikely to yield benefits for your program, dramatically reducing time and investment often wasted on trial and error experimentation. What’s more, the customized insights you’ll get from Quadrant 2® can help you avoid the risk of having to revise your solubility enhancement approach after Proof of Concept – a costly pitfall that can require up to 12 months of added time and incur additional costs in the range of $500,000 to $600,000. Quadrant 2® analyzes the molecular structure, as well as the physical and chemical characteristics of a compound based on the following information:

  • API chemical structure
  • Physicochemical properties
  • Full-scale molecular modeling based on Quantum and Molecular Dynamic (MD) simulations
  • Exclusive excipient descriptor database developed by Patheon

The Quadrant 2® model has been confirmed via a cross-verification/model validation approach with more than 70 commercially available molecules. Validation studies have proven that the Quadrant 2® technology selection tool is more than 90% accurate and the Quadrant 2® excipient selection tool is more than 80% accurate. We can complete computational modeling in as little as two weeks. Learn more about whether our Quadrant 2® program may be a good fit for your molecule by getting in touch with us!  

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