Particle Size reduction: Overcoming formulation challenges at all stages

At Patheon, by Thermo Fisher Scientific, we offer particle size reduction solutions for all stages of API development and commercial manufacture. Micronization can provide the uniform particle characteristics that are fundamental when manufacturing a formulation-enabling API. Carefully defined particle size distribution can help improve flow properties, which are essential in drug product process development and can improve solubility to increase your product’s bioavailability. Within our site in Florence, SC, we possess a range of milling capabilities from laboratory to production scale to support your size reduction needs. We can achieve a wide range of particle sizes from simple deagglomeration through coarse grinding to micronization via a range of capabilities including:

  • Spiral jet milling
  • Opposed jet milling
  • Air classifying milling
  • Pin milling
  • Hammer milling
  • Conical milling

Within our site in Cork, Ireland, we can also support from a European base with:

  •  Air classifier milling
  •  Pin milling
  •  Hammer milling

Our in-line particle size monitoring allows:

  • Real time analysis and control of the milling process
  • Feedback systems to control particle size distribution
  • Defining of slurry milling endpoint

Successfully managing particle size distribution requires extensive expertise and experience. Work with our scientists – plus a range of technology choices – to address your product’s individual needs. We can help you optimize the performance of your product.

Learn more about the importance of particle size in our recent whitepaper, “How Can You Avoid the Fallout From Incompatibility Between Your API and Its Formulation?”