Route Scouting: Creating your road map to an efficient process

Establishing the best synthetic route for your molecule is the basis for a reliable supply throughout the product’s life cycle. During route scouting, the following considerations are important when selecting the optimal pathway:

  • Safety
  • Efficiency, purity and costs
  • Ease of optimization and scale up
  • IP review
  • Security of supply of raw materials
  • Impact on waste and the environment

Thermo Fisher Scientific’s experienced chemists will first seek to establish historical process work and conduct searches of scientific literature to identify synthetic route options. These options are then presented to clients in priority order, highlighting the key benefits of each. Following a phase of laboratory work to assess the on-paper routes, one or two will be selected for further, more detailed laboratory assessment and optimization. The final route choice to move into more formal development is made in conjunction with the client and based on number of criteria. Our focus is always to carry out just sufficient development work for your molecule’s phase of development.

Regardless of whether you require early phase material or late phase and commercial supply, we have the capabilities to meet your API needs. Contact us to discuss your route scouting needs.

Learn more about the importance of accurate route scouting in our whitepaper, “How Can You Avoid the Fallout From Incompatibility Between Your API and Its Formulation?”