Sanjay Konagurthu, Ph.D.

Sr. Director, Science & Innovation, Pharma Services
Oregon, USA

Key roles and responsibilities

  • Scientific leader and technical subject matter expert, leading initiatives to improve solubility and bioavailability of poorly soluble drugs using enabling technologies
  • Direct activities related to material science characterization and physical pharmacy to solve performance, manufacturability or stability issues
  • Support strategic direction of global science and technology team
  • Lead thought leadership for publications, white papers, scientific conferences, webinars and IP related activities
  • Advise and consult on technical issues related to pre-formulation, formulation, process development and commercial manufacturing
  • Lead the predictive computational modeling group – Patheon Quadrant2®, ASAP stability for packaging and shelf-life predictions, Process modeling for pharmaceutical unit operations, Physiologically-based Pharmacokinetic (PBPK) Modeling

Professional highlights

  • Joined Thermo Fisher Scientific in 2013 and has more than twentytwo years of experience managing the development of drug compounds from discovery through commercialization
  • Launched proprietary Patheon Quadrant2® solution solubility enhancement platform for Thermo Fisher Scientific
  • Performed and managed formulation and process development for range of new chemical entities and lifecycle management of marketed products
  • Designed and conducted experiments in zero-gravity for NASA, training and personally flying on NASA’s KC-135 to conduct such experiments; cited by NASA in the annual microgravity report
  • Visiting researcher in advanced separation technologies at the University of Twente, Netherlands
  • Eight patent/patent applications, author or co-author of more than thirty-five publications, posters, and webinars
  • Awarded first place in research paper competition held by the American Association for the Advancement of Science, and best paper and citation from the North American Membrane Society

Education

  • Doctor of Philosophy in chemical engineering from the University of Colorado in Boulder
  • Bachelor’s degree in chemical engineering from the Indian Institute of Technology Madras (Chennai)

Scientific expertise

  • Oral drug delivery
  • Drug product development
    • Pre-formulation, formulation, process development, scale-up, tech transfer & commercialization
  • Solubility enhancement technologies
    • Amorphous solid dispersions by spray-drying
    • Hot-melt extrusion
    • Size-reduction
    • Lipid-based systems
    • Complexation
  • Oral modified release
    • Multiparticulate delivery
    • Osmotic delivery
    • Taste masking
    • Fast-dissolving dosage forms
  • Lifecycle management
  • Designing novel drug delivery systems
    • Nano-milling
    • Process miniaturization
  • Process development and scale-up
    • Novel process design & implementation
    • Design of experiments
    • Technology transfer