The information you provide to the chat will be collected and recorded to improve your experience and for quality assurance. Please read our privacy policy to see how we are storing and protecting your data.
How can we help you today?
Discover our new oral solid dose (OSD) development capabilities at our Bend, Oregon site.
Search Patheon
Recent searches
Clear History
Suggestions
All Results
Recent searches
Clear History
Suggestions
All Results
Search
US | EN
How Well Should You Understand Your Crystallization Process (and Solid-State Properties)?
Webinar On Demand
Crystallization is the most common unit operation for isolation and purification of solid intermediates and active pharmaceutical ingredients (APIs). As the end point of both the chemical development process and later manufacturing, the quality of the API delivered has a direct impact upon drug product formulation development and manufacturing.
A well-designed crystallization process and sufficient knowledge of the solid-state properties of a drug substance are essential to ensure high product purity and that the desired crystal modification is delivered consistently. Since the particle size distribution of the product depends upon both the solvent/solute system used and process parameters and equipment properties, crystallization can be employed to engineer particles precisely and with the right properties that ensure the optimum performance of the drug product.
Key Learning Objectives:
- Understand the typical progression of crystallization process development over the drug development timeline
- Determine what information is required when, and how to obtain it
- Learn how the physical properties of the API influence the choice of process and how processes can be used to tailor API powder properties
Author
Dr. Ing. habil. Matthew Jones, Crystallization Expert, Patheon, by Thermo Fisher Scientific