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Hot melt extrusion (HME) technology, originally adapted from the food and plastics industries, has become increasingly valuable in the healthcare sector due to its effectiveness in developing novel pharmaceutical formulations. HME is a continuous manufacturing process in which active ingredients, polymers, and processing aids are fed into the extruder and subjected to high shear and temperatures, forming a homogeneous matrix with the desired characteristics.
The rapid growth of hot melt extrusion technology in the pharmaceutical industry is driven by its ability to overcome many challenges associated with traditional drug manufacturing methods. With a thorough understanding of the process, HME can be utilized to modify properties that enhance solubility, prevent abuse, and adjust the release profile, ultimately leading to the development of high-quality pharmaceutical formulations that are both safe and effective for patients.
Our new white paper dives into HME and its pharmaceutical applications and explores the capabilities of Thermo Fisher Scientific as a CDMO partner for drug development.
